Purpose: To describe ocular complications in patients with human immunodeficiency virus (HIV) infection before and after highly active antiretroviral therapy (HAART).
Materials and Method: We retrospectively reviewed the medical records of 261 patients who underwent HAART and visited our clinic between April, 2007 and March, 2010, and recorded ocular complications, CD4 cell counts, visual acuity and other relevant patient information.
Results: Befor HAART patients were found to have the following conditions: HIV retinopathy (41 cases), cytomegalovirus (CMV) retinitis (23 cases), and others (6 cases); and after HAART HIV retinopathy (5 cases), CMV retinitis (16 cases), Immune recovery uveitis (IRU) (4 cases), and others (9 cases). The average CD4⁺ T-cell counts at diagnosis of CMV retinitis were 45.2/μl before and 116.7/μl after HAART.
Conclusions: Since a substantial number of patients develop CMV retinitis after the initiation of HAART, we need to examine patients to check for either the onset or reactivation of CMV retinitis and IRU even after HAART.
Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc) 116: 721-729, 2012.