Abstract

Volume.117 Number.1

Original article : Clinical science

Minute Granular Lesions of the Retinal Pigment Epithelium Related to Choroidal Hyperpermeability in Patients with Central Serous Chorioretinopathy
Muneyasu Takeda, Yui Sato
Souen Muneyasu Eye Clinic

Purpose: To investigate the relationship between increased permeability of choroidal vessels revealed by indocyanine green angiography (ICGA) and lesions of retinal pigment epithelium (RPE) revealed by Retro-mode (RM) in the eyes of patients with central serous chorioretinopathy (CSC).
Design: A retrospective cross-sectional study.
Patients and Methods: We examined the minute granular lesions (MGLs) of the RPE using RM imaging (scanning laser ophthalmoscopy), in relation to the choroidal hyperpermeability visualized by indocyanine green angiography (ICGA) in 40 eyes of 20 Japanese patients with CSC. We classified them into two groups: eyes (25 eyes) with various retinal lesions and eyes without retinal lesions (15 eyes).
Results: MGLs of the RPE in RM imaging were seen in 38 of 40 eyes (95%). The MGLs were detected in all 25 eyes in the group of various retinal lesions, and in 13 of 15 eyes (87%) in the group without retinal lesions. The area of MGLs exceeded the choroidal hyperpermeability in 18 eyes (45%), was the same as choroidal hyperpermeability in 15 eyes (38%), while 7 eyes (17%) had no hyperpermeability.
Conclusions: Choroidal hyperpermeability may be a possible cause of MGLs in the eyes of patients with CSC.
Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc) 117: 44-49, 2013.

Key words
Central serous chorioretinopathy, Choroidal hyperpermeability, Retro mode imaging (scanning laser ophthalmoscopy), Minute granular lesions of the retinal pigment epithelium (MGLs)
Reprint requests to
Muneyasu Takeda, M.D. Souen Muneyasu Eye Clinic. Branz Souen Station East, West-15, North-10 Chuo-ku, Sapporo 060-0010, Japan