Abstract

Volume.117 Number.10

Original article : Clinical science

Clinical Efficacy of Travoprost-Timolol Fixed Combination on Ocular Hypotensive Agents and Ocular Surface Agents in Japanese Glaucoma Patients
Takashi Kanamoto1, Yoshiaki Kiuchi2, Ikuko Ichioka3, Toru Onishi4, Kenji Osada5, Wataru Kimura6, Tatsunori Suehiro7, Manabu Nagaya8, Atsushi Hirota9, Satoshi Mukai10, Teruyuki Miyoshi11, Hironori Yoshida11
1 Department of Ophthalmology, Hiroshima Kinen Hospital
2 Department of Ophthalmology, Hiroshima University Hospital
3 Ichioka Eye Clinic
4 Onishi Eye Clinic
5 Osada Eye Clinic
6 Kimura Eye and Internal Medicine Hospital
7 Department of Ophthalmology, Asa-Shimin Hospital
8 Nagaya Eye Clinic
9 Hirota Eye Clinic
10 Department of Ophthalmology, Shobara-Red Cross Hospital
11 Miyoshi Eye Clinic

Purpose: To investigate the clinical effects of travoprost-timolol fixed combination on ocular hypotensive agents, ocular surface agents and adherence in Japanese glaucoma patients.
Methods: 28 Japanese glaucoma patients, who had used topical prostaglandin F2α analogue (28 eyes; PG group), were assigned to treatment with travoprost-timolol fixed combination. Reduction of intraocular pressure (IOP), grades of conjuctival follicle, conjuctival injection and keratoepitheliopathy, as well as interviews for topical administration, were evaluated. 38 patients, who switched from the topical prostaglandin F2α analogue and a beta-blocker to travoprost-timolol fixed combination (38eyes; PG+BB group) were also evaluated in the same manner.
Results: While IOP was significantly reduced in the PG group, IOP was not changed in the PG+BB group. Both groups showed no significant changes in scores for conjuctival follicle, keratoepitheliopathy, or interview.
Conclusion: These results suggest that travoprost-timolol fixed combination reduces IOP and produces low toxicity on the ocular surface.
Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc) 117: 793-798, 2013.

Key words
Glaucoma, Travoprost, Tomolol, Fixed combination, Intraocular pressure, Ocular surface, Interview
Reprint requests to
Takashi Kanamoto, M.D.　Department of Ophthalmology, Hiroshima Kinen Hospital. 1-4-3 Honkawa-cho, Naka-ku, Hiroshima 730-0802, Japan
Received: 23 October 2012. Accepted in revised form: 10 May 2013.
Nihon Ganka Gakkai Zasshi 117: 793-798,2013