Purpose: To analyze and evaluate the characteristics of intestinal bacterial flora in patients with high myopia and myopic choroidal neovascularization (mCNV)
Subjects and methods: We comparatively analyzed the intestinal flora of a high myopia group (n=36; mean age, 50.9 years; male, 13; mean eye axial length, 29.7 mm) versus a control group (n=33; mean age, 39.8 years; male, 14; mean eye axial length, 25.4 mm) and a patient group with a history of mCNV (n=15; mean age, 49.2 years; male, 7; mean eye axial length, 30.0 mm) versus a group with no such history (n=54; mean age, 44.6 years; male, 20; mean eye axial length, 27.0 mm).
Results: In the high myopia group, the abundance ratios of g_Bacteroides and g_Anaerostipes were significantly higher, whereas the abundance ratios of g_Collinsella, f_Streptococcaceae.g_, g_Lactococcus, f_Ruminococcaceae.Other, f_Desulfovibrionaceae.Other, g_Serratia, and g_Ralstonia were significantly lower. In the mCNV patient group, the abundance ratio of g_Holdemania was significantly higher, whereas the abundance ratios of o_Clostridiales.Other.Other and g_Turicibacter were significantly lower.
Conclusions: The observed higher abundance of g_Bacteroides in the intestinal bacterial flora of the high myopia patient group in which more patients were women contradicted our prediction. It is very interesting result and warrants further analysis.
Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc) 122: 733-743, 2018.