Background: Although the eyelid is a common site of sebaceous carcinoma, reports on patients with sebaceous carcinoma in the lacrimal region are rare. Here, we report the case of a patient with rapidly growing sebaceous carcinoma in the lacrimal region.
Patient: The patient was a 76-year-old female who noticed a mass in the left lacrimal region 6 months prior and presented at the Department of Ophthalmology of Kyushu University Hospital. The subcutaneous mass in the left lacrimal region was palpable, and magnetic resonance imaging (MRI) showed a mass that was 14 mm long with unclear margins. After 3 months, the mass increased to 26×21×33 mm and progressed to the left medial orbit, nasolacrimal duct, ethmoid sinus, and frontal sinus, and the patient was diagnosed with sebaceous carcinoma by biopsy. No lesions were observed on the eyelids or lacrimal caruncles, and no other lesions were observed using whole-body positron emission tomography (PET). Although the tumor shrank after heavy particle radiotherapy at a total dose of 64 Gy, lymph node metastases was observed in the left submandibular region, and cervical dissection and chemoradiotherapy were performed.
Conclusions: Sebaceous carcinoma may develop in the lacrimal region. As this condition may progress rapidly, caution should be exercised.
Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc) 125: 117-121, 2021.