A Review
Herpes Simplex Virus Evolved to Form Neuronal Latency
Kozaburo Hayashi, Yoshikazu Shimomura
Department of Ophthalmology, School of Medicine, Kindai University
Acyclovir or related antivirals eliminate herpes simplex virus (HSV) replication effectively, however, lifelong latency of HSV in neurons is still problematic. Recent progress in molecular analyses suggest that this may be the road to solve latency related morbidities. We briefly summarize recent trends in the progress in molecular analysis, focusing on corneal herpes.
Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc) 121:695-706, 2017.
Key words
Herpes simplex virus-1 (HSV-1), Latency, Latency-associated transcripts (LATs), Infected cell protein 0 (ICP0), MicroRNA (miRNA)
Reprint requests to
Kozaburo Hayashi, M.D., Ph.D. 1-26-8 Chofu-shi, Chofugaoka, Tokyo 182-0021, Japan
Received: 6 September 2016. Accepted in revised form: 20 April 2017.
Nihon Ganka Gakkai Zasshi
121: 695-706,2017
