A Review
Bioinformatics on New Human Adenoviruses Causing Nosocomial Infection
Koki Aoki1, Hisatoshi Kaneko2,3, Nobuyoshi Kitaichi4,5, Hidemi Watanabe6, Susumu Ishida1,5, Shigeaki Ohno5
1 Department of Ophthalmology, Hokkaido University Graduate School of Medicine
2 Department of Ophthalmology, Fukushima Medical University School of Medicine
3 Hobara Eye Clinic
4 Department of Ophthalmology, Health Sciences University of Hokkaido
5 Department of Ocular Inflammation and Immunology, Hokkaido University Graduate School of Medicine
6 Division of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University
Human adenovirus (HAdV) causing epidemic keratoconjunctivitis is limited to D and E species. Recent progress in bioinformatics revealed that these viruses attach to the host with fibers, infiltrate the host cells via RGD (Arg-Gly-Asp) motif of penton base, and reveal their serological reaction by hexons. Loops 1 and 2 are the variable regions of each hexon. The possibility that a novel adenovirus later named HAdV-52 was transmitted over the wall of species' from monkeys to humans was reported. The recombination of the above three hot spots introduces novel types such as HAdV-53, -54, and -56. Boinformatics may provide rapid genotyping in nosocomial infection, predicting future epidemics, and an estimate of the therapeutic target molecules in the near future.
Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc) 117: 721-726, 2013.
Key words
New adenovirus, Nosocomial infection, Hexon, Penton, Fiber
Reprint requests to
Koki Aoki, M.D. 4-3 Minami, 5 Hondohri Shiroishi-ku, Sapporo 003-0026, Japan
Received: 31 January 2013. Accepted in revised form: 12 April 2013.
Nihon Ganka Gakkai Zasshi
117: 721-726,2013
