Volume.121 Number.4

Original article : Clinical science

Amniotic Membrane Transplantation for Corneal and Conjunctival Diseases: Classification of Application and Outcomes from Analysis of 95 cases
Kazuomi Hanada1,2, Noriko Nishikawa2, Nobuhito Ishii2, Tsugiaki Utsunomiya2, Akitoshi Yoshida2
1 Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University
2 Department of Ophthalmology, Asahikawa Medical University

Purpose: To evaluate the indications and outcomes of amniotic membrane (AM) transplantation for corneal and conjunctival diseases.
Subjects and methods: Ninety-five eyes of ninety patients who underwent AM transplantation between January 2007 and May 2016 were included in this study. The surgical procedures, diagnosis and postoperative outcomes were investigated retrospectively.
Results: Transplantation was conducted in three surgical procedures. AM patch, for the promotion of corneal re-epithelialization, was performed in 14 cases with persistent epithelial defects. Thirteen cases healed with total epithelialization. Corneal perforation was noted in Stevens-Johnson syndrome and cured with keratoplasty. AM graft for basement membrane supply, was performed in 72 cases. Of these, 32 cases had been followed for at least one year after AM graft out of which pterygium recurred at one year in 5. Conjunctival tumor recurred in 3 out of 17 cases, and was treated with a repeated of AM graft. AM stuff for substrate supply to the deep corneal layer, was performed in 9 cases with corneal perforation. Leakage of aqueous humor was cured in all 9 cases. Seven cases had keratoplasty performed after the AM stuff and recovered completely. The other 2 cases were observed without additional surgery. There were no complications due to the AM transplantation during the course of treatment in any of the 95 cases.
Conclusion: AM transplantation is applied in three different procedures. Each of these was effective in achieving the corneal and conjunctival reconstruction designed for it.
Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc) 121: 359-365, 2017.

Key words
Amniotic membrane transplantation, Persistent epithelial defect, Pterygium, Conjunctival tumor, Corneal perforation
Reprint requests to
Kazuomi Hanada, M.D. Department of Medicine and Engineering Combined Research Institute, Asahikawa Medical University. 2-1-1-1 Midorigaoka-Higashi, Asahikawa-shi, Hokkaido 078-8510, Japan