Background: We report 3 cases of ischemic retinal vein occlusion with decreased non-perfusion area(NPA)following anti-vascular endothelial growth factor (VEGF) therapy.
Case1: After 3 monthly ranibizumab treatment, the NPA following branch retinal vein occlusion decreased in size. Photocoagulation (PC) was performed to residual NPA, following which, there was no increase to the NPA.
Case2: After 3 monthly aflibercept treatment, the NPA following central retinal vein occlusion (CVO) decreased in size. PC was performed to residual NPA, but in spite of the treatment, the NPA increased 4 months after PC.
Case3: After 3 monthly ranibizumab injections, NPA following hemi CVO decreased in size. PC was performed to residual NPA, but, in spite of the treatment, the NPA increased in size 6 months after PC. Additional PC was performed to the increased NPA, because retinal neovascularization was noted after 16 months.
Conclusions: Anti-VEGF therapy can decrease NPA. This may suggest that anti-VEGF therapy may improve the retinal circulation temporarily. However, in two cases the NPA increased in size even though PC was performed for the residual NPA. Further investigation will be required to confirm the adaptation and timing of PC.
Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc) 121:546-552, 2017.