Abstract

Volume.124 Number.1

Original article : Clinical science

Long-term Effect of Corneal Collagen Cross-linking on Bullous Keratopathy
Kentaro Abe1, Takashi Ono1,2, Ryohei Nejima1, Yosai Mori1, Kazunori Miyata1
1 Miyata Eye Hospital
2 Department of Ophthalmology, The University of Tokyo, Graduate School of Medicine

Purpose: To evaluate the long-term efficacy of pain relief of the corneal collagen cross-linking (CXL) in bullous keratopathy.
Patients and methods: We included 11 patients who had undergone CXL at their discretion, instead of corneal transplantation, from September 2011 to October 2015 at Miyata Eye Hospital. The patients were followed up over 2 years. Intraocular pressure (IOP), central corneal thickness (CCT), and intensity and frequency of pain were retrospectively examined at baseline and at month 1, 3, 6, 12, and 24. The intensity and frequency of pain were rated using the numerical rating scale that is an 11-point scale ranging from 0 (min.) to 10 (max.).
Results: The 11 eyes of 11 patients (male, 5; female, 6) with an average age of 79.5±10.9 years were evaluated. The IOP was 14.0±5.4 mmHg at baseline and showed no significant change after the surgery. The CCT was 790.1±171.2 μm at baseline and showed no significant change after the surgery. The mean scores of the intensity and frequency of pain at baseline were 4.9±3.2 and 3.9±2.7, respectively, and significantly improved at month 1 (1.1±2.1 and 1.0±1.8, respectively), and improved to 0.0±0.0 2 years after the surgery.
Conclusion: CXL on bullous keratopathy effectively suppressed pain for a long time period.Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc) 124: 15-20, 2020.

Key words
Bullous keratopathy, Corneal collagen cross-linking, Pain relief, Long-time efficacy
Reprint requests to
Kentaro Abe, M. D. Miyata Eye Hospital. 6-3 Kurahara-cho, Miyakonojo-shi, Miyazaki-ken 885-0051, Japan