Background：Previously, neovascularization of the iris（NVI）was evaluated using slit lamp microscopy and fluorescent contrast radiography；however, accurate and frequent evaluation has been difficult using these methods. We report on our experience of evaluating two cases of NVI over time using anterior segment optical coherence tomography angiography（AS-OCTA）.
Case 1：A 62-year-old man underwent pars plana vitrectomy and intraoperative pan-retinal photocoagulation for vitreous hemorrhage associated with proliferative diabetic retinopathy. Preoperatively, NVI was confirmed on the pupillary margin and at 3 o'clock of the iris during AS-OCTA. Subsequent follow-up observations confirmed that it gradually decreased over time postoperatively.
Case 2：A 75-year-old man underwent anti-vascular endothelial growth factor（VEGF）injections for macular edema and neovascular glaucoma accompanying ischemic central retinal vein occlusion. AS-OCTA performed prior to the onset of neovascular glaucoma confirmed vascular visualization from the pupillary margin to 6 o'clock. The regression of NVI was also observed after the anti-VEGF injections.
Conclusions：We were able to evaluate NVI over time using AS-OCTA. Thus, we believe that it could be used as one of the effective means of testing for the early diagnosis of NVI and to determine treatment effects for this condition.
Nippon Ganka Gakkai Zasshi（J Jpn Ophthalmol Soc）124：802-807, 2020.